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Isthmian League
Premier Division
Season 1980-81
| | P | W | D | L | F-A | Pts |
| 1 | Slough Town | 42 | 23 | 13 | 6 | 73-34 | 82 |
| 2 | Enfield | 42 | 23 | 11 | 8 | 81-43 | 80 |
| 3 | Wycombe Wanderers | 42 | 22 | 9 | 11 | 76-49 | 75 |
| 4 | Leytonstone & Ilford | 42 | 19 | 12 | 11 | 78-57 | 69 |
| 5 | Sutton United | 42 | 19 | 12 | 11 | 82-65 | 69 |
| 6 | Hendon | 42 | 18 | 10 | 14 | 66-58 | 64 |
| 7 | Dagenham | 42 | 17 | 11 | 14 | 79-66 | 62 |
| 8 | Hayes | 42 | 18 | 8 | 16 | 45-50 | 62 |
| 9 | Harrow Borough | 42 | 16 | 11 | 15 | 57-52 | 59 |
| 10 | Bromley | 42 | 16 | 9 | 17 | 63-69 | 57 |
| 11 | Staines Town | 42 | 15 | 9 | 18 | 60-61 | 54 |
| 12 | Tooting & Mitcham United | 42 | 15 | 8 | 19 | 49-53 | 53 |
| 13 | Hitchin Town | 42 | 14 | 10 | 18 | 64-62 | 52 |
| 14 | Croydon | 42 | 12 | 15 | 15 | 51-51 | 51 |
| 15 | Dulwich Hamlet | 42 | 13 | 12 | 17 | 62-67 | 51 |
| 16 | Leatherhead | 42 | 12 | 14 | 16 | 36-50 | 50 |
| 17 | Carshalton Athletic | 42 | 14 | 8 | 20 | 57-82 | 50 |
| 18 | Barking | 42 | 13 | 12 | 17 | 58-72 | 49 |
| 19 | Harlow Town | 42 | 11 | 15 | 16 | 53-66 | 48 |
| 20 | Walthamstow Avenue | 42 | 13 | 7 | 22 | 50-81 | 46 |
| 21 | Boreham Wood | 42 | 10 | 13 | 19 | 46-69 | 43 |
| 22 | Woking | 42 | 11 | 7 | 24 | 40-69 | 37 |
Barking: 2 points deducted Woking: 3 points deducted
Enfield and Dagenham promoted to the Alliance Premier League
Bishop's Stortford and Billericay Town promoted from Division One
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